A new gel-based vasectomy has proven effective in a group of monkeys, raising hopes it could one day provide a permanent but easily reversible male contraceptive option in humans. Vasalgel works by plugging the vas deferens, the two tiny tubes that convey sperm into a male's semen, researchers said. The gel "doesn't break down. It just sets up a little more, and sticks where you inject it," said lead researcher Catherine VandeVoort. She's a professor of obstetrics and gynecology with the University of California, Davis School of Medicine. Sixteen male rhesus macaque monkeys injected with the non-hormonal gel have proven incapable of reproduction, according to the study findings.

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No females have become pregnant in the males' presence, even though they were housed together for at least one breeding season -- about 6 months. "We're over two years in a lot of these males we injected with this, and so far they've all remained infertile," said VandeVoort. "We know that because we check the parentage of every baby that's born at the primate center." VandeVoort is also a scientist with the California National Primate Research Center at UC Davis. Traditional vasectomies either sever, crush or tie off the vas deferens, causing tissue damage that can be difficult to reverse, VandeVoort said. But researchers hope to revise the Vasalgel plug to the point where a simple solution of water and baking soda would flush it out of the vas deferens, easily restoring a man's fertility, said study co-author Elaine Lissner.

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The gel plug has been successfully flushed out of male rabbits in animal testing, but reversibility has not yet been perfected in primates, said Lissner, founder and trustee of the Parsemus Foundation, the nonprofit group funding development of the gel. The focus of the current study was to see whether Vasalgel would effectively prevent conception, Lissner and VandeVoort said. "This tells us whatever challenges we face, the bottom line is it has worked and been safe in animals similar to humans," Lissner said. The Parsemus Foundation, based in Berkeley, Calif., funded the primate study. Source: http://www.webmd.com/men/news/20170207/a-plug-instead-of-a-snip-for-male-birth-control

Saturday, May 16, 2026

Prednisone: The Generic Form Of Prednisone Explained

Prednisone is the generic name of the medication sold under the brand name Prednisone. Generic medications contain the same active ingredient at the same dose and strength as their brand name counterparts and must meet the same FDA standards for quality, purity, and bioequivalence. The development and approval of generic drugs play an important role in making effective treatments more accessible and affordable for patients. Allergy treatment has advanced considerably over the past several decades. Early antihistamines were effective but caused significant drowsiness. Modern second-generation antihistamines provide comparable or superior symptom control without the sedating side effects that limited their predecessors. Other treatment modalities include nasal corticosteroid sprays, which reduce airway inflammation, and allergen immunotherapy, which gradually desensitizes the immune system through controlled exposure to specific allergens over time. The pharmacological action of prednisone is the basis for its use in treating conditions within the category of corticosteroids. Understanding the mechanism by which the active compound produces its therapeutic effects helps patients appreciate why the medication needs to be taken consistently and at the correct dose to achieve the best results. Switching between brand name and generic versions of a medication is generally considered safe when the products are bioequivalent, but patients should inform their doctor if they notice any differences in effect after a formulary change. Some patients with conditions requiring precise drug levels in the blood may be monitored more closely during transitions. For most patients, however, approved generics provide equivalent therapeutic benefit to the brand name product. The https://mednewwsstoday.com/corticosteroids/ section on corticosteroids covers both brand name and generic treatment options, giving patients a complete picture of what is available. Cost, insurance coverage, and pharmacy availability are practical factors to discuss with a pharmacist when filling a prescription for prednisone.
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