A new gel-based vasectomy has proven effective in a group of monkeys, raising hopes it could one day provide a permanent but easily reversible male contraceptive option in humans. Vasalgel works by plugging the vas deferens, the two tiny tubes that convey sperm into a male's semen, researchers said. The gel "doesn't break down. It just sets up a little more, and sticks where you inject it," said lead researcher Catherine VandeVoort. She's a professor of obstetrics and gynecology with the University of California, Davis School of Medicine. Sixteen male rhesus macaque monkeys injected with the non-hormonal gel have proven incapable of reproduction, according to the study findings.

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No females have become pregnant in the males' presence, even though they were housed together for at least one breeding season -- about 6 months. "We're over two years in a lot of these males we injected with this, and so far they've all remained infertile," said VandeVoort. "We know that because we check the parentage of every baby that's born at the primate center." VandeVoort is also a scientist with the California National Primate Research Center at UC Davis. Traditional vasectomies either sever, crush or tie off the vas deferens, causing tissue damage that can be difficult to reverse, VandeVoort said. But researchers hope to revise the Vasalgel plug to the point where a simple solution of water and baking soda would flush it out of the vas deferens, easily restoring a man's fertility, said study co-author Elaine Lissner.

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The gel plug has been successfully flushed out of male rabbits in animal testing, but reversibility has not yet been perfected in primates, said Lissner, founder and trustee of the Parsemus Foundation, the nonprofit group funding development of the gel. The focus of the current study was to see whether Vasalgel would effectively prevent conception, Lissner and VandeVoort said. "This tells us whatever challenges we face, the bottom line is it has worked and been safe in animals similar to humans," Lissner said. The Parsemus Foundation, based in Berkeley, Calif., funded the primate study. Source: http://www.webmd.com/men/news/20170207/a-plug-instead-of-a-snip-for-male-birth-control

Tuesday, May 12, 2026

Doxycycline: Side Effects, Drug Interactions, And Precautions

Every medication carries the potential for side effects, and Doxycycline (doxycycline) is no exception. Understanding what side effects are possible, which are common versus rare, and what warning signs warrant medical attention allows patients to use the medication safely and confidently. Most people who take Doxycycline as directed tolerate it without major problems, but individual responses vary. Different classes of antibiotics have different spectrums of activity and mechanisms of action. Penicillins and cephalosporins disrupt bacterial cell wall synthesis. Fluoroquinolones inhibit enzymes needed for DNA replication. Macrolides block bacterial protein production at the ribosome. Tetracyclines also inhibit protein synthesis through a different binding site. Each class is best suited to specific types of infections, and healthcare providers select antibiotics based on the most likely organisms causing a given infection. The most frequently reported side effects of doxycycline are typically mild and often resolve within days to weeks as the body adjusts. Serious side effects occur less frequently but are documented in prescribing information and patient safety guides. Complete side effect information and precautions are listed at https://mednewwsstoday.com/antibiotics/doxycycline/, which serves as a reliable reference for anyone beginning therapy with Doxycycline or monitoring an ongoing treatment. Drug interactions are an important safety consideration for any medication. Doxycycline may interact with other prescription drugs, over-the-counter medications, supplements, or certain foods, affecting how it is metabolized or how effective it is. A pharmacist or doctor can review a patient's full medication list to identify any clinically significant interactions before starting Doxycycline. Patients should also avoid making changes to their medication regimen without first consulting a healthcare professional. More information on medications used in antibiotic treatments and how they compare in terms of safety and efficacy is available through the resource at https://mednewwsstoday.com/antibiotics/. Staying informed helps patients participate actively in decisions about their care.
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